SPOKANE, Wash. (AP) — Siyani Chambers scored 11 points, including five straight in the final 2 minutes, and 12th-seeded Harvard won its second NCAA tournament game in history, upsetting fifth-seeded Cincinnati 61-57 on Thursday in the East Regional.

Wesley Saunders led the Crimson (27-4) with 12 points as Harvard pulled off an upset for the second straight year. Last year, Harvard upset New Mexico as a 14 seed.

The Crimson became the first Ivy League school with NCAA tournament wins in consecutive years since Princeton in 1983-84.

Harvard never trailed after the opening moments. They played with confidence and scrap against the Bearcats, who shared the American Athletic Conference regular season title.

Sean Kilpatrick led Cincinnati (27-7) with 18 points, but the Bearcats failed to win a tournament game for the second straight year.

NORTH DAKOTA STATE 80, OKLAHOMA 75 (OT)

SPOKANE, Wash. (AP) — Lawrence Alexander hit a 3-pointer with 11 seconds left to force overtime and freshman Carlin Dupree scored four points in the final 75 seconds as No. 12 seed North Dakota State knocked off Oklahoma 80-75 Thursday night.

The Bison (26-6) picked up their first NCAA tournament win by rallying in the final minute and then outlasting the No. 5 seed Sooners in overtime. Alexander finished with a career-high 28 points, but it'll be his falling-down, fist-pumping celebration after the tying 3-pointer that will be replayed in Fargo for years.

Dupree came on in the closing seconds of overtime after Taylor Braun fouled out. He hit two free throws and scored on a difficult baseline leaner with 41 seconds left.

Cameron Clark led Oklahoma (23-10) with 25 points.

MICHIGAN ST. 93, DELAWARE 78

Adreian Payne scored a career-high 41 points to get Michigan State off to a solid start in the NCAA tournament.

Payne, a 6-foot-10 senior, scored 12 straight points in the first half to help the fourth-seeded Spartans (27-8) to an 18-point lead.

He set an NCAA tournament record by making all 17 of his free throws and broke the program's tournament scoring record, set previously by Greg Kelser in 1979.

Devon Saddler had 21 points and Davon Usher added 20 for the 13th-seeded Blue Hens (25-10).

Travis Trice scored 13 of his 19 points in the second half for the Spartans.

SOUTH REGIONAL

DAYTON 60, OHIO ST. 59

BUFFALO, N.Y. (AP) — Vee Sanford scored on a layup with 3.8 seconds left to lift 11th-seeded Dayton.

Sanford finished with 10 points, while Dyshawn Pierre led the Flyers (24-10) with 12 points in a matchup of Ohio schools separated by about 75 miles.

The sixth-seeded Buckeyes (25-10) had one last chance to pull out the victory, but Aaron Craft's driving 10-footer hit off the backboard and rolled off the rim as the buzzer sounded.

Sam Thompson scored 18 points and Craft added 16 for Ohio State, which was eliminated after one game for only the third time in its 26 tournament appearances.

SYRACUSE 77, W. MICHIGAN 53

BUFFALO, N.Y. (AP) — Syracuse's backcourt of Trevor Cooney and Tyler Ennis combined for 34 points and the Orange defense clamped down.

Western Michigan (23-10), the Mid-American Conference champion, had won 14 of 16 games and was in the NCAA tournament for the first time in a decade.

The third-seeded Orange (28-5) forced 11 turnovers in the opening half and scored 13 points off them in running out to a double-digit lead before the midpoint of the period.

Cooney led the Orange with 18 points, hitting 4 of 8 from beyond the arc, and Ennis had 16 points and six assists with one turnover.

The Orange used an 18-4 spurt over 10 minutes to take control and led 40-21 at halftime.

Shayne Whittington and Tucker Haymond led Western Michigan with 11 points apiece.

PITTSBURGH 77, COLORADO 48

ORLANDO, Fla. (AP) — Talib Zanna scored 16 of his 18 points in the opening half, helping ninth-seeded Pittsburgh build a 28-point lead.

The Panthers (26-9) shot 51 percent and played stifling defense.

Colorado (23-12) was eager to make amends for an early exit from the tournament a year ago, but had no answers for the 6-foot-9 Zanna. The Pitt center made six of seven shots in the first half, and the Panthers didn't have any difficulty finishing off the overwhelmed Buffaloes.

Josh Scott led the eighth-seeded Buffaloes with 14 points, however Colorado couldn't overcome a subpar performance from Askia Booker.

FLORIDA 67, ALBANY 55

ORLANDO, Fla. (AP) — Dorian Finney-Smith scored 16 points, most of them on dunks, and top-seeded Florida used a second-half surge to beat 16th-seeded Albany.

The Gators (33-2) showed some vulnerability, though, while extending their school-record winning streak to 27 games.

Coach Billy Donovan's team sleepwalked through the first half, swapping the lead back and forth with the pesky Great Danes, but Florida's bench provided a much-needed spark.

Finney-Smith, the Southeastern Conference's sixth man of the year, was 6-of-10 shooting. Freshman guard Kasey Hill, who wasn't sure he would be able to play because of turf toe, chipped in 10 points.

Patric Young finished with 10 points and 10 rebounds, his first double-double of the season. Casey Prather (16 points) and Scottie Wilbekin (10) also reached double figures for Florida.

DJ Evans led Albany (19-15) with 21 points and seven rebounds.

WEST REGIONAL

WISCONSIN 75, AMERICAN 35

MILWAUKEE (AP) — Ben Brust scored 17 points and second-seeded Wisconsin devastated American with a 22-5 run to close the first half.

The second-seeded Badgers (27-7) recovered from a brief first-half rut and seven-point deficit to extinguish the dreams of the 15th-seeded Eagles (20-13).

After Wisconsin was ousted in the first round last year as a No. 5 seed, Brust made sure his senior season didn't end the same way. He attacked the glass for baskets on consecutive possessions, ending with a three-point play with 3:33 left in the first half to give Wisconsin a 23-20 lead.

The Badgers shot 57 percent from the field in the second half.

John Schoof had 11 points for American.

OREGON 87, BYU 68

MILWAUKEE (AP) — Elgin Cook scored a career-high 23 points for seventh-seeded Oregon.

Joseph Young had 19 points for the Ducks (24-9), who had to stage a big comeback to beat the Cougars 100-96 in overtime in December. There was no comeback needed this time, with Oregon turning away every charge by BYU in the second half.

Cook, a native of Milwaukee, is the son of former NBA All-Star Alvin Robertson.

Tyler Haws scored 19 points for 10th-seeded BYU (23-12), which returned to the NCAA tournament after a one-year absence. Matt Carlino added 15 points.